1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID

1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID - Names and Identifiers

Name	[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid
Synonyms	AKOS BRN-1191 1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID 5-Borono-1-methyl-3-(trifluoromethyl)-1H-pyrazole 1-Methyl-3-(trifluoromethyl)pyrazole-5-boronic acid 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-boronic acid (1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)boronic acid [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid 3-(trifluoroMethyl)-1-Methyl-1H-pyrazol-5-yl-5-boronic acid B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid Boronic acid, B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-
CAS	344591-91-9
InChI	InChI=1/C5H6BF3N2O2/c1-11-4(6(12)13)2-3(10-11)5(7,8)9/h2,12-13H,1H3

1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID - Physico-chemical Properties

Molecular Formula	C5H6BF3N2O2
Molar Mass	193.92
Density	1.46±0.1 g/cm3(Predicted)
Melting Point	132-137°C
Boling Point	311.3±52.0 °C(Predicted)
Flash Point	142.042°C
Vapor Presure	0mmHg at 25°C
Appearance	powder or crystals
pKa	6.97±0.58(Predicted)
Storage Condition	2-8°C
Refractive Index	1.463

1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID - Risk and Safety

WGK Germany

1-METHYL-3-TRIFLUOROMETHYLPYRAZOLE-5-BORONIC ACID - Introduction

[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is an organic compound with the chemical formula C6H6BF3N2O2.

Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 197.83g/mol
-melting point: 139-141 ℃
-Boiling point: 344.8 ℃ (expected value)
-Solubility: Soluble in common solvents such as water, methanol and ethanol

Use:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is an organoboron reagent, widely used in organic synthesis.
-it can be used as a catalyst or raw material to participate in carbene reaction, coupling reaction, hydrogenation reaction and other organic synthesis reaction.

Preparation Method:
A common method for preparing [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is by reacting sodium borate with 1-methyl-3-trifluoromethylpyrazole. Specific steps are:
1. first dissolve sodium hydroborate in water or ethanol;
2. add 1-methyl -3-trifluoromethylpyrazole;
3. Stir the reaction at an appropriate temperature for a period of time;
4. The product is obtained by filtering the precipitate.

Safety Information:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is relatively stable at room temperature, but high temperatures, open flames and strong oxidants should be avoided.
-Use when wearing appropriate protective measures, such as wearing chemical goggles and protective gloves.
-Avoid contact with skin, eyes and inhalation of vapors or dust during operation.
-In case of accidental contact, rinse immediately with plenty of water and seek medical assistance nearby.

Last Update：2024-04-10 22:29:15